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The increase in GSH content can be achieved from GSSG through GR catalyzation or de novo biosynthesis through the -glutamyl cycle

10.5093/ed2011v17n2a4 48

Balbi B, Bason C, Balleari E, Fiasella F, Pesci A, Ghio R, et al

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These two facts prove non-involvement of ROS in N2a death 40

Among well-known senomorphic compounds, telomerase activators [120], caloric restriction diets [121] and mimetics [122], proteasome activators [123], autophagy activators [124], antioxidants [125], mTOR inhibitors [126], sirtuin activators [127], and anti-inflammatory agents targeting inflammaging /senoinflammation [128] can be mentioned