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Description

Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation

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Successively, it was shown that TIGAR, a protein involved in the inhibition of the glycolytic pathway, could limit starvation-induced ATG by means of its ability to indirectly suppress ROS production (Bensaad et al., 2009)

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This model was evaluated by: i) Serum ALT and bilirubin, ii) flow cytometry to define the immune cell composition in the liver and blood iii) H&E staining to assess steatosis, inflammation and ballooning iv) human/mouse aSMA and human Collagen-3 to asses mouse and human hepatic stellate cells activation and v) human CK8/18 to asses Mallory bodies formation

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