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It isn't ethical to give a placebo to a group of people who really need treatment for cancer

Acta Neuropathol 2016

There is some association with hot flashes and increased risk of heart disease and bone loss

Oxid Med Cell Longev (2019) 11:7518510

Because L-Citrulline largely bypasses first-pass liver metabolism, it raises plasma L-Arginine levels more efficiently than direct L-Arginine supplementation, gram for gram - a pharmacokinetic advantage that's driven by growing research interest in this amino acid specifically

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