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Clinical trials have demonstrated significant efficacy, with patients losing approximately 15% of body weight with semaglutide 2.4 mg (STEP 1 trial) and up to 20% with tirzepatide (SURMOUNT-1 trial) when combined with lifestyle modifications

doi: 10.1016/j.atherosclerosis.2018.05.023 61 TangDKangR

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Cell 162 , 10661077 (2015)