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Intriguingly, under conditions of caspase-1 deficiency or pharmacological inhibition, an alternative pathway emerges: the inflammasome redirects its signaling to activate caspase-3, which subsequently processes GSDME to execute pyroptosis [80]

Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations

This effect has been noted in rat studies [4]

The number of patients requiring reintubation for successive pulmonary failure was recorded, as was mortality

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Lancet Neurol (2023) 22(3):26882