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The cyclical and unpredictable nature of relapse and remission (Feritas et al

Aqp4 is a key regulator of water homeostasis at the bloodbrain barrier, and its downregulation is directly associated with vasogenic edema, whereas the integrity of the extracellular matrix constrains vascular permeability and inflammatory cell infiltration

However, it is not a cure and symptoms may return over time

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Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes