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Key enzymatic antioxidants include glutathione peroxidase and glutathione reductase (GSH-Px), catalase (CAT), and superoxide dismutase (SOD), all of which play a crucial role in neutralizing ROS and preserving cellular integrity [41, 42]

In contrast, Hmox1 RNA and protein levels progressively increased to become higher than in WT mice at ~36 and 52 h (Figure 7a)

Sepsis mortality is strongly associated with the degree of organ dysfunction

The positive correlations in human CSF of Xan and several monoamines including 5-HIAA have been noted earlier (Niklasson et al., 1983) and between UA and 5-HIAA (Degrell and Nagy, 1990)

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