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Miao F, Wang R, Cui G, Li X, Wang T, Li X

Talk to your provider before stopping the medication if pregnancy is planned

Downregulation or deficiency of pyruvate kinase leads to ATP depletion which in turn affects cell viability as well as accumulation of the glycolytic intermediates (2,3-diphosphoglycerate (2,3-DPG) that eventually leads to impaired glycolytic flux 46

Role of superoxide anion in the generation of other reactive species Superoxide anion (O2) which is constantly being generated through endogenous processes and exogenous sources can through different pathways or chain reactions cause the formation of several other reactive species.15 It can directly produce hydroxy radical (OH) (O2 + 2e OH) or indirectly from hydrogen peroxide which results from its dismutation by SOD (H2O2 + e OH), through Fenton reaction which occurs in the presence of Fe2+ (Fig

Conflict of interest The authors declare that this study was conducted in the absence of any commercial or financial relationships that could be construed as conflicts of interest

Both compounds, administered at doses of 5 and 25 mg/kg, significantly reduced colonic damage, observed macroscopically, microscopically, and biochemically