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Adverse effects of low-dose methotrexate: a randomized trial

Biol Chem Hoppe Seyler 370 , 109113 (1989)

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Oral administration allows the peptide to interact directly with the gastrointestinal lining, targeting areas of injury and promoting mucosal repair, angiogenesis, and barrier strengthening

Similarly, in lung fibrosis, inhibition of the Nrf2 pathway is closely associated with elevated levels of oxidative stress in fibrotic tissues, which in turn triggers the abnormal deposition of fibrous components such as collagen, leading to a post-ferroptotic state in lung tissue cells [8, 9]