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MDVs are transported to peroxisomes via the outer membrane mitochondrial anchoring protein ligase (MAPL) or are trafficked to lysosomes via the Parkin pathway, binding to lysosomes that degrade their cargoes [53]

Another avenue is advanced surface engineering to create coatings that are selectively permeable to contaminants but act as a robust physical and chemical barrier to biological macromolecules, thus preventing the non-specific interactions that initiate toxicity.186 Fig

doi:10.1038/s41398-019-0466-x Lyte M, Daniels KM, Schmitz-Esser S

Conventional medical approaches to treating Parkinson's disease aim to replace the lost dopamine, but fall short of addressing the ongoing destruction of dopaminergic neurons

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As shown in Figure 6D, GO enrichment analysis revealed that immune response, immune system process, and defense response were the top three signaling pathways suppressed in the DSS-MSC group