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Always apply retinol at night (its deactivated by sunlight) and wear SPF during the day to protect the fresh skin youre revealing

It upregulates vascular endothelial growth factor (VEGF) and its receptor VEGFR2, directly promoting angiogenesis the formation of new blood vessels at injury sites

Eight weeks is a long enough window to observe effects, and four weeks off is a real break that gives the methylation cycle time to normalize before the next block

*Results vary

Vegan or vegetarian diets that exclude animal products Digestive conditions such as pernicious anaemia, Crohn disease, or coeliac disease Stomach surgery or weight-loss surgery that reduces intrinsic factor Ageing stomach lining or medicines that lower acid, including proton-pump inhibitors and metformin A simple blood test confirms your B12 status and guides treatment

Chen JY, Hwang JV, Ao-Ieong WS, et al