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In mice with U87 gliomas, HCCDs specifically concentrated within brain tumors

Data from the Minnesota Green Tea Trial showed a 6.7% incidence of ALT elevation in postmenopausal women consuming 843 mg/day EGCG, with polymorphisms in the COMT and UGT1A4 genes contributing to interindividual variability in toxicity (245)

Plant J 38:779789 Maruyama-Nakashita A, Nakamura Y, Yamaya T, Takahashi H (2004b) Regulation of high-affinity sulphate transporters in plants: towards systematic analysis of sulphur signaling and regulation

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Another tight barrier, composed of tanycytes and astrocytes, at the circumventricular organs surrounding the brain ventricles may prevent blood-borne substances from easily migrating to nearby brain areas