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Description

The model is available in PEtab format 50 at All model analyses, parameter estimation and identifiability analysis have been carried out using the dMod 51 package for R

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M.et al (2017)

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Additionally, IL-6 can initiate signaling through soluble IL-6R, expanding the range of responding cell types [103], and the primary downstream pathway activated by is the JAK/STAT pathway [104]

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Skipping doses on busy days, then trying to "catch up" with a double dose later

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It can be assumed that increased demand in tissue results in a decrease in its plasma concentration

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