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External resources for researchers Related research products Disclaimer Used solely for in vitro experiments and cannot be: Used in clinical trials involving humans Administered to humans as part of an experiment or investigation Supplied to another party for human investigational use

Tight junctions, formed by proteins including claudins, occludins, and zonula occludens proteins, are the primary gatekeepers of intestinal permeability

41 A family history of anxiety is one important determinant, as children of anxious parents have been found to be significantly more likely to have anxiety disorders