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Both molecules have real signal

Metformin attenuates fluctuating glucose-induced endothelial dysfunction through enhancing GTPCH1-mediated ENOS recoupling and inhibiting NADPH oxidase

Exact protocols vary

(2017) "Design and synthesis of NNMT inhibitors with tunable cell permeability." Published in Journal of Medicinal Chemistry

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What also helped to crystallise Jerne's ideas were his discussions with Ole Maale (figure 9), an immunologist at the State Serum Institute, whose laboratory he joined as an assistant after completing his medical degree