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Serum levels of acetone, acetoacetic acid, and hydroxybutyric acid significantly declined in active, acetoacetic acid, and remission patients

This aggressive first-pass metabolism slashes its plasma half-life to a meagre 30 minutes, reducing its chances of reaching peripheral nerves or muscle tissues in therapeutic amounts

Moreover, stereotaxic lactate injection into the third ventricle induces PD-like phenotypes, including motor impairments, in murine models 8

PMID: 36507835 Nanoscale Targeting glutamine metabolism combined with a nanoradioenhancer in radioresistant hepatocellular carcinoma

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PLoS One 19 , e0276832 (2024)