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doi: 10.1038/s41598-022-17244-6 32 CandelloneAGirolamiFBadinoPJarriyawattanachaikulWOdoreR

After being treated with salicylic acid, the plants made a lot more cardenolide and had higher amounts of proline, phenol, and flavonoids

NO-ASA is thought to exert its anticancer effects by an esterase catalyzed release of an electrophile quinone methide (QM) intermediate that selectively reacts with and depletes intracellular GSH [15, 22]