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The document specifies requirements for the submission of variation applications and establishes a risk-based approach to post-market variations

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Western blot Cells were harvested and proteins were extracted using cell lysis buffer supplemented with 0.3% phenylmethylsulfonyl fluoride and proteinase and phosphatase inhibitors

eGFR, estimated glomerular filtration rate

Its primary physiological functions include promoting glucose-dependent insulin secretion, enhancing hepatic glycogen synthesis, and increasing the buffering capacity of adipose tissue for lipids