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When researchers and staff internalize this philosophy, clinical trials not only become more ethical but also more efficient, ultimately contributing to improved data quality and accelerated advancements in medical research

Dafachronic acid and temperature regulate canonical dauer pathways during Nippostrongylus brasiliensis infectious larvae activation

Toxicol Appl Pharmacol 2004, 194:1023

Constipation, while less common than diarrhea, may also occur and can be particularly problematic in patients with pre-existing constipation issues

J Appl Physiol 112(1):197203 Salehpour M, Khodagholi F, Zeinaddini Meymand A, Nourshahi M, Ashabi G (2018) Exercise training with concomitant nitric oxide synthase inhibition improved anxiogenic behavior, spatial cognition, and BDNF/P70S6 kinase activation in 20-month-old rats