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Results from the LMER models with the same effect size direction in the discovery and replication cohorts were then meta-analysed using fixed-effects meta-analysis implemented via the R package metafor (v.4.40)

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At the initial baseline visit, serial venous sampling performed after oral d 3 -l-carnitine challenge revealed rapid increases in plasma concentrations of d 3 -l-carnitine, and subsequent increases in d 3 -BB and d 3 -TMAO following a lag phase (Figure 1, AC, filled circles)

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Supplementary Table 1