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Unsupervised multivariate statistical methods such as principal component analysis (PCA), self-organizing maps (SOM) and hierarchical cluster analysis (HCA) are valuable for exploring patterns and clusters, as well as for addressing data quality concerns such as outliers and batch effects

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Figure 3 Recent research suggests that this change in function is driven by changes in metabolism

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Vitamin D deficiency may well be an important factor in autoimmune rheumatic disease, including initial disease development and worsening the disease once present.[238] TH-17 Activation and Dampening As discussed in part 6, T-helper 17 (TH-17) is a subset of T-helper cells producing IL-17