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Using milk from genetically modified mice, Hassiotou et al

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Behavioral intervention consisted of counseling by a dietitian or similarly qualified healthcare professional every 4 weeks via in-person visits or telephone on adherence to a reduced-calorie diet (500 kcal deficit a day relative to the energy expenditure estimated at randomization) and increased physical activity (150 minutes a week encouraged, for example, walking), both recorded daily (via a diary, app or other tools, which were reviewed during counseling sessions)

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1) are largely based on the WCRF/AICR systematic reviews and Continuous Update Project reports, with additional evidence from systematic reviews and large pooled analyses published since the most recent WCRF/AICR reports

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