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As a single transmembrane receptor, the low-density lipoprotein receptor (LDLR) plays an important role in maintaining the homeostasis of intracellular cholesterol metabolism, in which exogenous cholesterol is internalized into the low-density lipoprotein (LDL) and taken up by the cell after binding to the LDLR on the cytosolic membrane [198]

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The PCA results emphasize the inherent variability within our dataset and provide insights into the primary factors driving the observed trends

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A potent neuroprotective effect of the autonomous C-terminal IGF-1Ec peptide has also been confirmed in brain ischaemia models

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