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Mechanistic plausibility is hypothesis generation, not clinical evidence

If you draw 50 units but 5 units of that is air, you are only injecting 45 units of solution, which is 10% less tirzepatide than intended

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Maar, K., et al

Because the needle stays in the fatty layer, there is less chance of catching a nerve or a blood vessel than with a deeper injection, which is one reason some clinicians prefer it for maintenance dosing