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However, in complexes with positively charged molecules, including certain DAMPs, DNA can become immunogenic (61, 142)

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85 This is of particular importance because some xenobiotics might impact the GI microbiota physiology without inducing dysbiosis: indeed, when fresh human faecal samples were incubated with antibiotics or with host-targeted drugs, all host-targeted drugs resulted in significant alterations of microbial gene expression, including genes involved in xenobiotic metabolism, despite minimal short-term effects on microbial community structure

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On the one hand, intestinal microbes modify BAs through enzymatic transformations

Relationships between lower plasma L-tryptophan levels and immune-inflammatory variables in depression