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A 2022 review identified only two studies that suggest a possible benefit, and both studies included only small numbers of people and had weaknesses in the research

With the exception of TLR3, all TLRs predominantly signal through the MyD88-dependent pathway

In addition, tumor-on-a-chip integrates tumor and stromal cells instead of healthy tissue cells, to mimic invasive tumor behaviour and TME dynamics (Li et al., 2023a

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