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Exp Toxicol Pathol 44: 273281

PubMed Vinogradova et al., 2008

Cmax of 13.28 pg/ml (predicted) vs

[3] Hyperpigmentation in B12 deficiency occurs as a result of (1) decreased levels of reduced glutathione which activates tyrosinase and results in increased melanin synthesis, (2) defect in transfer of melanin from melanocytes to keratinocytes resulting in pigment incontinence, (3) increased biopterin in B12 deficiency increases hydroxylated phenylalanine which results in hyperpigmentation

This makes copper peptides modulator of multiple cellular pathways a valuable ingredient in anti-aging skincare formulations and reduction in fine lines

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