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Results Co-treatment with IKE and the oxidized form of vitamin C, DHAA, sensitizes tumor cells to ferroptosis Certain cell lines of tumor origin, such as prostate cancer cells (PCa) [19] and glioblastoma multiforme (GBM) cells [20], present as resistant to system x c - inhibitors such as erastin and IKE

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Additionally, traditional in vitro models often treat lung cells with CSE under submerged conditions, rather than at the airliquid interface, an important physiological aspect of the air-blood barrier environment