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4.6.8 Mitochondrial Function and Energy Metabolism Energy metabolism is dysregulated early in the course of ALS as a result of decreased appetite, increased energy expenditure, and hypothalamic dysfunction, among other complex factors [295,296,297,298,299]

Qiao C-M, Sun M-F, Jia X-B, Li Y, Zhang B-P, Zhao L-P

The promises and challenges of human brain organoids as models of neuropsychiatric disease

1 2 Physiological Reviews

Nevertheless, the pooled analysis of 16 trials suggested improvements in the summary measure of patients' global functioning (assessed with the Clinical Global Impressions [CGI-I] scale) after 12 and 24 weeks of (but not after 52 weeks) of ALCAR treatment (1-3 g/day) and in cognitive performance (assessed with the Mini-Mental State Examination [MMSE] scale) after 24 weeks (but not at 12 or 52 weeks) (104)

MHISC is a collective group of five International and European recognized surgeons