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Read more: AUTHORS: Luis Alfonso Prez Gonzlez, Mara Antonia Martnez Pascual, Elena Toledano Macas, Rosa Cristina Jara Laguna, Montserrat Fernndez Guarino, Stefano Bacci, Jorge Naharro Rodriguez, Mara Luisa Hernndez Bule Maneesh Paul

Pharmacogenomics 9(8):11131132

doi:10.1016/j.intimp.2023.109685

The method according to any one of claims 7 to 11, characterized in that one produces the magnesium salt of N 5 , N 10 -methylene-5,6,7,8-tetrahydrofolic acid by reaction at room temperature of 5,6,7,8- Tetrahydrofolic acid in water with a compound selected from the group consisting of alkali metal hydroxides, alkali metal carbonates, alkali metal bicarbonates, ammonia and organic, nitrogen-containing bases, such as pyridine, triethylamine, triethanolamine, then reacting the salt solution thus prepared with formaldehyde, and then one aqueous solution of a magnesium salt adds, the magnesium salt of N 5 , N 10 -methylene-5,6,7,8-tetrahydrofolic acid precipitates

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