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C3 is of particular importance in the complement system because of its role in creating both C3 convertase and C5 convertase, which are essential for the formation of the membrane attack complex

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On the other hand, a substantial decrease in pulmonary NF-B p65, TNF, IL-1, and iNOS was marked in ARNI groups indicating for the first time the anti-inflammatory effects of ARNI that could decrease pulmonary inflammation precipitated by PQ

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