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Muller HL, Handwerker G, Wollny B, Faldum A, Sorensen N

"Replication Bypass of the N-(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase ." Biochemistry

B.KyseniusK.BillingsJ

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This multi-pathway approach is exciting from a therapeutic standpoint its like orchestrating an overall healing response rather than targeting one single receptor

In addition, to strengthen the mechanistic insights derived from GEM and FBA, validation using metabolic flux assays (e.g., Seahorse XF analysis and LC-MS/MS metabolomics) would be beneficial