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This paper describes possibly the first clinical study to use a hyperpolarized 13 -labelled substrate

By integrating recent advancements in understanding the molecular pathways and highlighting promising therapeutic agents, this review provides a solid foundation for future research

Liver and Brain Dysfunction When oxygen levels drop below 2%, the liver reduces hemoglobin production, leading to hypoxia, impaired energy production, and increased red blood cell (RBC) destruction.76 Chronic liver damage is linked to processing RBC byproducts like hemoglobin, iron, and cholesterol, which accumulate in organs like the liver, pancreas, and bone marrow, disrupting metabolism

doi: 10.1016/S0015-3796(84)80059-1 157

Dysfunctional LLPS-associated proteins (e.g., FMRP, TIA1, G3BP1) and aberrant stress granules have been implicated in psychiatric disorders such as autism spectrum disorder, schizophrenia, and depression (Darnell et al., 2011

Drosophila melanogaster glutamate-cysteine ligase activity is regulated by a modifier subunit with a mechanism of action similar to that of the mammalian form