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The combination of an anti-PD-1 antibody with lumacaftor (in micromolar doses), an FDA-approved small molecule inhibitor of DUSP18, has been shown to synergistically enhance antitumor immunity

The administration of Loigolactobacillus coryniformis K8 has shown promising effects, such as increasing the IgA response in correlation with the activation of TGF-, a key signaling molecule involved in immune regulation and tolerance

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