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Shows the highest GLUT4 translocation and IGF-1R sensitivity

doi: 10.1073/pnas.200364497 78 GarrettL

It defends cellular macromolecules against exogenous and endogenous reactive oxygen and nitrogen species

DNA damage uncouples the mitogenic response to IGF-I in MCF-7 malignant breast cancer cells by switching the roles of PI3 kinase and p21WAF1/Cip1

Abstract Purpose This review provides an update on the current clinical, epidemiological and pathophysiological evidence alongside the diagnostic, prevention and treatment approach to chemotherapy-induced peripheral neuropathy (CIPN)

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