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The investigators reported that LR3-IGF-1 produced greater anabolic effects than native IGF-1 across both administration modes, with the differential most pronounced under once-daily injection conditions

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For GSDME overexpression in mice liver, 1 10 9 PFU of adenovirus was injected into Gsdme -/- mice via tail vein and mice were used for experiments after 5 days of maintaining under controlled conditions