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One of the effects of vitamin B-12 deficiency is lethargy or the lack of energy

However, supplementation has not been shown to improve cognitive function in older adults who are not deficient

Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions

GH secretagogues stimulate fat oxidation and may enhance energy expenditure during calorie restriction or fasting. Heffernan et al., Frontiers in Endocrinology 4