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Figure 3 6.1 Based on epigenetic reprogramming Unlike classical adaptive immune memory, which relies on antigen receptor gene rearrangement, trained immunity operates through epigenetic modifications that increase chromatin accessibility at gene loci following primary stimulation

The Groupe dEtudes Thrapeutiques des Affections Inflammatoires Digestives

ALOX15 was recently reported to play an essential role in exacerbating I/R-induced cerebral injury 259 and ischemia-induced myocardial injury 260 by driving the peroxidation of PL-PUFAs and inducing ferroptosis, providing compelling evidence supporting the viability of targeting ALOX15 to treat I/R-induced injury in these tissues

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The currently approved pharmacological treatments for PD are summarized in Table 1

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