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Alcohol and medications are common causes of fat deposition in hepatocytes

Key gaps include lack of longitudinal human datasets, validated phenotype biomarkers, optimal timing/duration of interventions, and pediatric safety/riskbenefit evidence, including uncertainty about applying adult antifibrotic drugs in children

B 13 (8), 34543470

Biochem Pharmocol 2003

HSPA9/mortalin/mtHSP70/GRP75 HSPA9, also known as mortalin, is a constitutive but inducible mitochondrial chaperone involved in multiple functions related to proteostasis and apoptosis

ALT and AST are indicators of hepatocyte injury, TBIL reflects bile metabolism and excretion, while ALB indicates the livers synthetic capacity [11]