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Free Radical Biol Med (2007) 42(7):93644

In rats, GCLC has a Km for glutamate that is about 10-fold higher than that of the GCL holoenzyme, which is higher than the cellular glutamate concentration in most tissues GCL is specific for the glutamyl moiety and is regulated physiologically by: (a) non-allosteric feedback competitive inhibition by glutathione (GSH) (Ki = 2.3 mM) which involves binding of GSH to the glutamate and another site on the enzyme [8, 9] and (b) availability of its precursor, cysteine [1]

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Low levels correlate with the progression of coronary artery disease, which was observed not only in individuals with coronary artery obstructions that required intervention, but also in people who were relatively young and apparently healthy

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Polycystic literally means "many cysts." In medical terms, it usually refers to a condition called polycystic ovary syndrome (PCOS)