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Scalcon V, Folda A, Lupo MG, Tonolo F, Pei N, Battisti I, et al

It has been proposed that magnesium inhibits TNF-a production, and zinc and calcium are known to bind inflammatory interleukins to suppress their production

Ann Neurol

doi: 10.1093/lambio/ovad140, 188

Experimental work indicates that statins disturb mitochondrial complexes, although this sits mainly in mechanistic studies rather than patient-level trial In clinic I treat these hypotheses as prompts to focus on whole-mitochondrial support sleep, nutrient-dense diet, physical activity matched to capacity, and careful review of polypharmacy rather than chasing every possible supplement

Site-specific operating conditions also impact chemical selection