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Vitamin D has been shown to induce a decrease in the production of pro-inflammatory cytokines including IL-1, IL-6, and TNF, and an increase in the secretion of the anti-inflammatory IL-10 [43,44,45,46,47,48,49,50]

For future studies, it is recommended to select earlier time points and a higher frequency to assess gene expression and mitochondrial functionality of PBMC following an LPS challenge, as the primary dynamics of the immune response occur immediately after the immune challenge

D.Marques-MagallanesJ

Participants received either 83 g (3,332 IU) vitamin D daily for 1 year (n = 31) or placebo (n =2 3)

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