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This vicious cycle accelerates maladaptive remodeling, underscoring the need for therapies that jointly preserve mitochondrial integrity and restore FAO homeostasis

Gardembas M, Rousselot P, Tulliez M, Vigier M, Buzyn A, Rigal-Huguet F, Legros L, Michallet M, Berthou C, Cheron N (2003) Results of a prospective phase 2 study combining imatinib mesylate and cytarabine for the treatment of Philadelphia-positive patients with chronic myelogenous leukemia in chronic phase

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This is in line with previous studies showing that Lactiplantibacillus plantarum dramatically increased the levels of both SOD and GSH-Px enzymes in the liver of mice 97

Fluoxetine-induced androgen deficiency may lead to the increased expression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1), which activates the pro-apoptotic factor p53 through deubiquitination and triggers germ cell apoptosis