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When NNMT depletes SAM in adipocytes, epigenetic regulation is disrupted potentially locking in gene expression patterns that favor energy storage over expenditure

1-MNA and S-(5-adenosyl)-L-methionine (SAH) were obtained from Cayman Chemical Company (Ann Arbor, MI, USA)

Rat or mouse bioavailability cannot define human bioavailability

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Not only is it a naturally occurring peptide with an established safety profile, but it's also available in meaningful concentrations that may help with age management