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[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Broadley D., McElwee K.J

The pills wont work for the same reason that people need to take insulin by injectionthe enzymes in your gut will just chew it up, says Katrin Svensson, PhD, an associate professor of pathology at Stanford University who directs a lab there that does preclinical research on peptides

Biguanide-derived neuroprotective agent (metformin) To mitigate neuroinflammation and mitochondrial dysfunction in PD, metformin was encapsulated into PLGA, which were further coated with BV2 microglial cell membranes to enhance the targeting efficiency to neuroinflammatory sites (BV2-metformin-loaded PLGA) for intranasal administration 19

10.1038/nrn1937 Nat

J.BottinoR.CasuA.CampanileN.CooperD

The BioSpectrum Imaging System (UVP, LLC) was used to detect signal of immunopositive protein bands