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Pharmacophores of reported HDAC inhibitors have three main components: A zinc-binding group (ZBG) that chelates with the zinc ion in the active site of the protein, a cap group that interacts with residues on the proteins outer surface, and a linker that connects the cap group and ZBG 19

10.2337/db19-1186 13 HommaT.FujiiJ

Critically, significantly higher vascularization was observed in the TCC group compared to the zinc oxide and control groups when average vascularization degree was compared

03 Heavy Metals Lead, arsenic, mercury, and cadmium introduced during synthesis

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