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4 Cantuti-CastelvetriL.FitznerD.Bosch-QueraltM.WeilM.-T.SuM.SenP.et al (2018)

By contrast, macrophage polarization, dictated by specific cytokine milieu and environmental cues, denotes a more specialized process in which activated macrophages differentiate along a continuous spectrum into distinct functional phenotypes (32,33)

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Epigenetic hijacking of core signaling hubs In tumor cell signaling networks, the PI3K-AKT-mTOR and RAS-RAF-MEK-ERK pathways are central to regulating cell growth, proliferation, and survival [103]

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Increased expression of VEGF stimulates angiogenesis, acting on dopamine D1 receptors, and may cause, among other things, dyskinesia, a major side effect of L-DOPA, which may further reduce the quality of life of PD patients under L-DOPA medication (Veith and Henderson 2019) Increased VEGF expression has been also documented in astrocytes, endothelial cells (ECs), and monocytes of MS patients, potentially contributing to BBB permeability and the onset of MS