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Further confirmation for cell cycle exit in response to AIIB2 was seen during a time-course experiment on 2D BME-coated transwells loaded with a human ileal organoid line, stably expressing the fluorescent ubiquitination based cell cycle indicator (FUCCI) reporter(Extended Data Fig

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4.1 Impaired brain metabolism leads to sleep disturbances Sleep is a physiologically active and regulated state during which consciousness and sensory processing are temporarily reduced to support essential homeostatic functions such as cellular repair, memory consolidation, and metabolic detoxification

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Although pepsin operates optimally at a pH of 232, it remains active at pH levels of 672, values compatible with those of the oral cavity and respiratory tract (whose pH is around 6472)