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A favorable A1C does not rule out hypoglycemic episodes

Liver histopathology was examined by a blinded pathologist

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The cycle threshold (CT) for the target genes ( SIRT-1 and CYP2E1 ) and the endogenous control GAPDH for each sample were detected and the relative quantitation of SIRT-1 and CYP2E1 mRNA expression levels was estimated by normalizing CT of each gene with the CT of GAPDH in each sample using the 2 CT method ( Hematoxylin and eosin stain (H& E) This stain was used for evaluation of liver architecture, inflammatory cell infiltration, vascular congestion and hepatocyte necrosis, apoptosis, steatosis, vacuolation, edema and malignant changes ( Perls prussian blue stain This stain was used for detection of iron in hepatic tissue

One mechanism which could lead to these properties was suggested to be the binding of beta-3-adrenergic receptors located on white fat and thus increasing the rate of metabolism in fat cells

[DOI] [PubMed] [Google Scholar] 24.Reifen R., Berkovich Z., Mandelberg A