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In cobalamin deficiency, the synthesis of methionine is impaired and toxic amino acid homocysteine accumulates [11]

10.3390/antibiotics12010177 67 GuoP.ZhangB.ZhaoJ.WangC.WangZ.LiuA.et al (2022)

Given that implanted chondrocytes are responsible for the generation of new cartilage in the defect site, it is not surprising that the quality of these cells critically affects the reparative results of ACI treatment (Davies and Kuiper, 2019)